Rate of cognitive decline in premotor Parkinson's disease: a prospective study (NEDICES).
Identifieur interne : 000812 ( Main/Exploration ); précédent : 000811; suivant : 000813Rate of cognitive decline in premotor Parkinson's disease: a prospective study (NEDICES).
Auteurs : Álvaro Sánchez-Ferro [Espagne] ; Julián Benito-Le N ; Elan D. Louis ; Alex J. Mitchell ; José Antonio Molina-Arjona ; Rocío Trincado ; Alberto Villarejo ; Félix Bermejo-ParejaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
Descripteurs français
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Age Factors, Aged, Aged, 80 and over, Cognition Disorders (etiology), Cognition Disorders (psychology), Depression (complications), Depression (drug therapy), Disease Progression, Educational Status, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Prospective Studies, Risk Factors, Sex Factors, Spain.
- MESH :
- geographic : Spain.
- complications : Depression, Parkinson Disease.
- drug therapy : Depression.
- etiology : Cognition Disorders.
- psychology : Cognition Disorders, Parkinson Disease.
- Age Factors, Aged, Aged, 80 and over, Disease Progression, Educational Status, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Risk Factors, Sex Factors.
Abstract
Previous research has documented cognitive impairment in the early stages of Parkinson's disease (PD). It is not known when this decline starts or if decline progresses at an accelerated rate during the premotor period of the disorder. In this population-based prospective study of older people (≥65 years) from the Neurological Disorders in Central Spain (NEDICES) cohort, we compared the rates of cognitive decline in 3 groups: (1) non-PD elderly controls; (2) prevalent PD patients (those diagnosed with the disease at baseline, 1994-95); and (3) premotor PD subjects (those diagnosed with the disease at follow up, 1997-98, but not at baseline). A 37-item version of the Mini-Mental State Examination (37-MMSE) was administered in the 2 visits of the study. From 2487 participants (age, 72.8 ± 6.0 years), including 2429 controls, we recruited 21 premotor PD cases, and 37 prevalent PD cases. At baseline, the mean 37-MMSE score was 28.5 ± 4.7 in prevalent cases, 28.1 ± 4.6 in premotor cases, and 29.9 ± 5.0 in controls (P = .046). During the 3-year follow-up period, there was a significant score decline of 2.4 ± 4.6 points in prevalent cases versus 0.2 ± 4.1 points in premotor cases and 0.3 ± 4.0 points in controls (Kruskal-Wallis test, P = .03). In the NEDICES cohort, cognitive test scores of prevalent PD cases declined at a rate above and beyond that observed in premotor PD cases and in controls. The rate of cognitive decline in premotor PD and controls was similar. Our data suggest that a decline in global cognitive function does not occur in premotor PD.
DOI: 10.1002/mds.25148
PubMed: 23239285
Affiliations:
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Le document en format XML
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Louis</name></author><author><name sortKey="Mitchell, Alex J" sort="Mitchell, Alex J" uniqKey="Mitchell A" first="Alex J" last="Mitchell">Alex J. Mitchell</name></author><author><name sortKey="Molina Arjona, Jose Antonio" sort="Molina Arjona, Jose Antonio" uniqKey="Molina Arjona J" first="José Antonio" last="Molina-Arjona">José Antonio Molina-Arjona</name></author><author><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name></author><author><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name></author><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1002/mds.25148</idno><idno type="RBID">pubmed:23239285</idno><idno type="pmid">23239285</idno><idno type="wicri:Area/PubMed/Corpus">000B30</idno><idno type="wicri:Area/PubMed/Curation">000B30</idno><idno type="wicri:Area/PubMed/Checkpoint">000831</idno><idno type="wicri:Area/Ncbi/Merge">003933</idno><idno type="wicri:Area/Ncbi/Curation">003933</idno><idno type="wicri:Area/Ncbi/Checkpoint">003933</idno><idno type="wicri:Area/Main/Merge">000812</idno><idno type="wicri:Area/Main/Curation">000812</idno><idno type="wicri:Area/Main/Exploration">000812</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rate of cognitive decline in premotor Parkinson's disease: a prospective study (NEDICES).</title><author><name sortKey="Sanchez Ferro, Alvaro" sort="Sanchez Ferro, Alvaro" uniqKey="Sanchez Ferro A" first="Álvaro" last="Sánchez-Ferro">Álvaro Sánchez-Ferro</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain. alvarosferro@hotmail.com</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Hospital 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Mitchell, Alex J" sort="Mitchell, Alex J" uniqKey="Mitchell A" first="Alex J" last="Mitchell">Alex J. Mitchell</name></author><author><name sortKey="Molina Arjona, Jose Antonio" sort="Molina Arjona, Jose Antonio" uniqKey="Molina Arjona J" first="José Antonio" last="Molina-Arjona">José Antonio Molina-Arjona</name></author><author><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name></author><author><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name></author><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (psychology)</term><term>Depression (complications)</term><term>Depression (drug therapy)</term><term>Disease Progression</term><term>Educational Status</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Prospective Studies</term><term>Risk Factors</term><term>Sex Factors</term><term>Spain</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Depression</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Educational Status</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Prospective Studies</term><term>Risk Factors</term><term>Sex Factors</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous research has documented cognitive impairment in the early stages of Parkinson's disease (PD). It is not known when this decline starts or if decline progresses at an accelerated rate during the premotor period of the disorder. In this population-based prospective study of older people (≥65 years) from the Neurological Disorders in Central Spain (NEDICES) cohort, we compared the rates of cognitive decline in 3 groups: (1) non-PD elderly controls; (2) prevalent PD patients (those diagnosed with the disease at baseline, 1994-95); and (3) premotor PD subjects (those diagnosed with the disease at follow up, 1997-98, but not at baseline). A 37-item version of the Mini-Mental State Examination (37-MMSE) was administered in the 2 visits of the study. From 2487 participants (age, 72.8 ± 6.0 years), including 2429 controls, we recruited 21 premotor PD cases, and 37 prevalent PD cases. At baseline, the mean 37-MMSE score was 28.5 ± 4.7 in prevalent cases, 28.1 ± 4.6 in premotor cases, and 29.9 ± 5.0 in controls (P = .046). During the 3-year follow-up period, there was a significant score decline of 2.4 ± 4.6 points in prevalent cases versus 0.2 ± 4.1 points in premotor cases and 0.3 ± 4.0 points in controls (Kruskal-Wallis test, P = .03). In the NEDICES cohort, cognitive test scores of prevalent PD cases declined at a rate above and beyond that observed in premotor PD cases and in controls. The rate of cognitive decline in premotor PD and controls was similar. Our data suggest that a decline in global cognitive function does not occur in premotor PD.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name><name sortKey="Mitchell, Alex J" sort="Mitchell, Alex J" uniqKey="Mitchell A" first="Alex J" last="Mitchell">Alex J. Mitchell</name><name sortKey="Molina Arjona, Jose Antonio" sort="Molina Arjona, Jose Antonio" uniqKey="Molina Arjona J" first="José Antonio" last="Molina-Arjona">José Antonio Molina-Arjona</name><name sortKey="Trincado, Rocio" sort="Trincado, Rocio" uniqKey="Trincado R" first="Rocío" last="Trincado">Rocío Trincado</name><name sortKey="Villarejo, Alberto" sort="Villarejo, Alberto" uniqKey="Villarejo A" first="Alberto" last="Villarejo">Alberto Villarejo</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Sanchez Ferro, Alvaro" sort="Sanchez Ferro, Alvaro" uniqKey="Sanchez Ferro A" first="Álvaro" last="Sánchez-Ferro">Álvaro Sánchez-Ferro</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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